Studies on inhibitory mechanism of microtubule inhibitors
نویسندگان
چکیده
Microtubules are key components of the cytoskeleton of eukaryotic cells and play important roles in many aspects of biological functions. Development of microtubule inhibitors, which interfere with microtubule assembly and disassembly specific in the M phase, is useful for the investigation of the biological function of microtubules and microtubule-associated proteins (MAPs) as well as for cancer therapy. Tryprostatin A (TPS-A, Fig. 1) was isolated as a microtubule inhibitor, but its inhibition mechanism was different from that of other conventional tubulin binders. In this review, we describe the possible role of TPSs as a biochemical tool and an anticancer drug. T. Usui
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تاریخ انتشار 2001